Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein (a) in vivo.

@article{Callow1995SitespecificMD,
  title={Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein (a) in vivo.},
  author={Matthew J. Callow and Edward M. Rubin},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 41},
  pages={23914-7}
}
In the formation of the lipoprotein(a) (Lp(a)) particle, apolipoprotein(a) (apo(a)) and apolipoprotein B (apoB) are covalently linked via a disulfide bond in both humans and human-apo(a)/apoB transgenic mice. Studies based upon fluorescent labeling of free cysteine residues have suggested that cysteine 3734 of the 4 carboxyl-terminal cysteines of apoB (Cys-3734, Cys-3890, Cys-4190, and Cys-4326) is the most likely candidate to form a disulfide bond with apo(a). However, other recent studies… CONTINUE READING

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In the formation of the lipoprotein(a ) ( Lp(a ) ) particle , apolipoprotein(a ) ( apo(a ) ) and apolipoprotein B ( apoB ) are covalently linked via a disulfide bond in both humans and human - apo(a)/apoB transgenic mice .
In the formation of the lipoprotein(a ) ( Lp(a ) ) particle , apolipoprotein(a ) ( apo(a ) ) and apolipoprotein B ( apoB ) are covalently linked via a disulfide bond in both humans and human - apo(a)/apoB transgenic mice .
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