Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome.

@article{Balog2009SitespecificMO,
  title={Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome.},
  author={Edward M. Balog and Elizabeth L Lockamy and David D Thomas and Deborah A. Ferrington},
  journal={Biochemistry},
  year={2009},
  volume={48 13},
  pages={3005-16}
}
The proteasome is a key intracellular protease that regulates processes, such as signal transduction and protein quality control, through the selective degradation of specific proteins. Signals that target a protein for degradation, collectively known as degrons, have been defined for many proteins involved in cell signaling. However, the molecular signals involved in recognition and degradation of proteins damaged by oxidation have not been completely defined. The current study used… CONTINUE READING
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