Site-specific mass tagging with stable isotopes in proteins for accurate and efficient protein identification.

@article{Chen2000SitespecificMT,
  title={Site-specific mass tagging with stable isotopes in proteins for accurate and efficient protein identification.},
  author={X Y Chen and Lloyd M. Smith and E. Morton Bradbury},
  journal={Analytical chemistry},
  year={2000},
  volume={72 6},
  pages={1134-43}
}
Proteolytic peptide mass mapping as measured by mass spectrometry provides a major approach for the identification of proteins. A protein is usually identified by the best match between the measured and calculated m/z values of the proteolytic peptides. A unique identification is, however, heavily dependent upon the mass accuracy and sequence coverage of… CONTINUE READING