Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

  title={Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation},
  author={Ivo A Hendriks and David Lyon and Clifford O. Young and Lars Juhl Jensen and Alfred C O Vertegaal and Michael L Nielsen},
  journal={Nature Structural &Molecular Biology},
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0–SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structural–predictive analyses revealed that lysines residing in disordered regions are preferentially targeted by SUMO, in notable contrast to other widespread lysine modifications. In our data set, we… CONTINUE READING
Highly Cited
This paper has 28 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 21 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 14 extracted citations

National supercomputing in Denmark

2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO) • 2018
View 3 Excerpts
Highly Influenced

Chromatin SUMOylation in heat stress: To protect, pause and organise?: SUMO stress response on chromatin.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2017
View 7 Excerpts
Highly Influenced

PTMD: A Database of Human Disease-associated Post-translational Modifications

Genomics, Proteomics & Bioinformatics • 2018
View 1 Excerpt


Publications referenced by this paper.