Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation.

@article{Hu2010SitespecificIB,
  title={Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation.},
  author={Ping Hu and Shino Shimoji and Gerald W. Hart},
  journal={FEBS letters},
  year={2010},
  volume={584 12},
  pages={2526-38}
}
Ser(Thr)-O-linked beta-N-acetylglucosamine (O-GlcNAc) is a ubiquitous modification of nucleocytoplasmic proteins. Extensive crosstalk exists between O-GlcNAcylation and phosphorylation, which regulates signaling in response to nutrients/stress. The development of novel O-GlcNAc detection and enrichment methods has improved our understanding of O-GlcNAc functions. Mass spectrometry has revealed O-GlcNAc's many interactions with phosphorylation-mediated signaling. However, mechanisms regulating O… CONTINUE READING
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Dynamic crosstalk between GlcNAcylation and phosphorylation: roles in signaling, transcription and human disease

  • S. Shimoji, K. Park, G. W. Hart
  • Curr. Signal Transduct. Therapy
  • 2010

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