Site-specific interaction of vaccinia virus topoisomerase I with base and sugar moieties in duplex DNA.

@article{Shuman1993SitespecificIO,
  title={Site-specific interaction of vaccinia virus topoisomerase I with base and sugar moieties in duplex DNA.},
  author={Stewart Shuman and Jeremy Turner},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 25},
  pages={18943-50}
}
Vaccinia DNA topoisomerase specifically binds and forms a covalent adduct at DNA sites containing a conserved sequence element 5'(C/T)CCTT decreases in the scissile strand. The molecular interactions that contribute to recognition of the CCCTT motif in a synthetic DNA substrate have been examined using modification interference, modification protection, and… CONTINUE READING