Site-specific initiation of DNA replication within the non-transcribed spacer of Physarum rDNA.

@article{Benard1995SitespecificIO,
  title={Site-specific initiation of DNA replication within the non-transcribed spacer of Physarum rDNA.},
  author={Marianne Benard and C Lagnel and G{\'e}rard Pierron},
  journal={Nucleic acids research},
  year={1995},
  volume={23 9},
  pages={1447-53}
}
Physarum polycephalum rRNA genes are found on extrachromosomal 60 kb linear palindromic DNA molecules. Previous work using electron microscope visualization suggested that these molecules are duplicated from one of four potential replication origins located in the 24 kb central non-transcribed spacer [Vogt and Braun (1977) Eur. J. Biochem., 80, 557-566]. Considering the controversy on the nature of the replication origins in eukaryotic cells, where both site-specific or delocalized initiations… CONTINUE READING

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