Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: model characterisation and in vivo effects of ibandronate on tumour growth.

@article{Neudert2003SitespecificHB,
  title={Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: model characterisation and in vivo effects of ibandronate on tumour growth.},
  author={Marcus Neudert and Christian Fischer and Burkhard Krempien and Frieder Bauss and Markus J. Seibel},
  journal={International journal of cancer},
  year={2003},
  volume={107 3},
  pages={468-77}
}
Animal models are important tools to study the development of bone metastases and to evaluate strategies for their prevention and treatment. We here describe a new model in which tumour inoculation is achieved by injection of cancer cells into the femoral artery. This approach results in the development of multiple osteolytic lesions in the distal femora… CONTINUE READING