Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes

@article{Breit1993SitespecificDI,
  title={Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes},
  author={Timo M. Breit and E J Mol and Ingrid L. M. Wolvers-Tettero and W. D. Ludwig and Elisabeth R van Wering and Jacques J. M. van Dongen},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={965 - 977}
}
Site-specific deletions in the tal-1 gene are reported to occur in 12-26% of T cell acute lymphoblastic leukemias (T-ALL). So far two main types of tal-1 deletions have been described. Upon analysis of 134 T-ALL we have found two new types of tal-1 deletions. These four types of deletions juxtapose the 5' part of the tal-1 gene to the sil gene promoter, thereby deleting all coding sil exons but leaving the coding tal-1 exons undamaged. The recombination signal sequences (RSS) and fusion regions… CONTINUE READING

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Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-ceU receptor c~B lineage

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