Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats.

@article{Yokooji2009SitespecificCO,
  title={Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats.},
  author={T. Yokooji and N. Mori and T. Murakami},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 7},
  pages={
          911-8
        }
}
  • T. Yokooji, N. Mori, T. Murakami
  • Published 2009
  • Medicine
  • The Journal of pharmacy and pharmacology
  • OBJECTIVES Methotrexate is reportedly a substrate for proton-coupled folate transporter/haem carrier protein 1 (PCFT/HCP1) and reduced folate carrier 1 (RFC1). In this study, we examined the contribution of PCFT/HCP1 and RFC1 in the intestinal absorption of methotrexate in rats. METHODS Western blot analysis was carried out to evaluate the protein levels of PCFT/HCP1 and multidrug resistance-associated protein 2 in brush-border membrane of rat small intestine. Mucosal uptake of methotrexate… CONTINUE READING
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