Site-specific cleavage of BMP4 by furin, PC6, and PC7.

  title={Site-specific cleavage of BMP4 by furin, PC6, and PC7.},
  author={Sylvia M Nelsen and Jan L Christian},
  journal={The Journal of biological chemistry},
  volume={284 40},
Bone morphogenetic proteins (BMPs) require proteolytic activation by members of the proprotein convertase (PC) family. Pro-BMP4 is initially cleaved at a site adjacent to the mature ligand domain (S1) and then at an upstream site (S2) within the prodomain. Cleavage at the S2 site, which appears to occur in a tissue-specific fashion, regulates the activity and signaling range of mature BMP4. To test the hypothesis that tissue-specific cleavage of pro-BMP4 is regulated by differential expression… CONTINUE READING


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