Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter.

@article{Schwartz1994SitespecificBO,
  title={Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter.},
  author={Ruth Schwartz and Matthew H. Sommer and Audra L. Scully and Deborah H. Spector},
  journal={Journal of virology},
  year={1994},
  volume={68 9},
  pages={5613-22}
}
We have previously demonstrated that the human cytomegalovirus (HCMV) immediate-early region 2 86-kDa protein (the IE2 86 protein) is the major transactivator of the HCMV early promoter for the 2.2-kb class of RNAs (open reading frame UL 112-113). Here we show that specific stimulation of this promoter by IE2 86 in transient-expression assays requires sequences located between nucleotides (nt) -113 and -58 relative to the transcription start site; this is also the major regulatory region for… CONTINUE READING
27 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…