Site-specific antidepressant effects of repeated subconvulsive electrical stimulation: potential role of brain-derived neurotrophic factor.

@article{Gersner2010SitespecificAE,
  title={Site-specific antidepressant effects of repeated subconvulsive electrical stimulation: potential role of brain-derived neurotrophic factor.},
  author={Roman Gersner and Erika Vikt{\'o}ria T{\'o}th and Moshe Isserles and Abraham Zangen},
  journal={Biological psychiatry},
  year={2010},
  volume={67 2},
  pages={125-32}
}
BACKGROUND Electroconvulsive therapy (ECT) is a very effective treatment for major depression. This method involves robust nonfocal stimulation of the brain and can normalize both neurochemical alterations and depressive behavior in animal models. We hypothesized that short stimulation sessions of specific reward-related brain sites might induce similar effects. METHODS In the present study we compared behavioral and neurochemical effects produced by ECT and by repeated stimulation of reward… CONTINUE READING

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