Site-specific antiatherogenic effect of probucol in apolipoprotein E-deficient mice

@article{Witting2000SitespecificAE,
  title={Site-specific antiatherogenic effect of probucol in apolipoprotein E-deficient mice},
  author={Witting and Pettersson and Letters and Stocker},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 8},
  pages={
          E26-33
        }
}
-The lipid-lowering antioxidant probucol can inhibit atherosclerosis in animals and restenosis in humans. However, probucol has been shown to promote atherosclerosis in the aortic root of apolipoprotein E-deficient (apoE-/-) mice. In the current study, we examined the effects of probucol on both lesion formation at 4 sites along the aorta and lipoprotein oxidation in the plasma and aortas of apoE-/- mice receiving a diet containing 21.2% (wt/wt) fat and 0. 15% (wt/wt) cholesterol without or… CONTINUE READING

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