Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites.

@article{Gronostajski1985SitespecificDB,
  title={Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites.},
  author={Richard M. Gronostajski and Samit Adhya and Kyosuke Nagata and R A Guggenheimer and Jerard Hurwitz},
  journal={Molecular and cellular biology},
  year={1985},
  volume={5 5},
  pages={964-71}
}
Nuclear factor I is a cellular site-specific DNA-binding protein required for the efficient in vitro replication of adenovirus DNA. We have characterized human DNA sequences to which nuclear factor I binds. Three nuclear factor I binding sites (FIB sites), isolated from HeLa cell DNA, each contain the sequence TGG(N)6-7GCCAA. Comparison with other known and putative FIB sites suggests that this sequence is important for the binding of nuclear factor I. Nuclear factor I protects a 25- to 30-base… CONTINUE READING
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