Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

@article{Persson2004SiteselectiveRO,
  title={Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.},
  author={Camilla Ulrika Persson and Catrine S{\"a}venhed and Annie Bourdeau and Michel L Tremblay and Boyka Markova and Frank D. B{\"o}hmer and Fawaz Gaj Haj and Benjamin G Neel and Ari Elson and C M Heldin and Lars R{\"o}nnstrand and Arne Ostman and Carina Hellberg},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 5},
  pages={2190-201}
}
The platelet-derived growth factor (PDGF) beta receptor mediates mitogenic and chemotactic signals. Like other tyrosine kinase receptors, the PDGF beta receptor is negatively regulated by protein tyrosine phosphatases (PTPs). To explore whether T-cell PTP (TC-PTP) negatively regulates the PDGF beta receptor, we compared PDGF beta receptor tyrosine phosphorylation in wild-type and TC-PTP knockout (ko) mouse embryos. PDGF beta receptors were hyperphosphorylated in TC-PTP ko embryos. Fivefold… CONTINUE READING