Site-selective nitration of tyrosine in human serum albumin by peroxynitrite.

  title={Site-selective nitration of tyrosine in human serum albumin by peroxynitrite.},
  author={Kui Jiao and Saraswathi Mandapati and Paul L. Skipper and Steven R Tannenbaum and John S. Wishnok},
  journal={Analytical biochemistry},
  volume={293 1},
Peroxynitrite, which is formed in biological systems by the reaction of nitric oxide with superoxide anion, is a highly reactive molecule that can lead to cell injury or cell death. Reactions of peroxynitrite under physiological conditions include nitration of tyrosine-containing proteins or peptides, and we have been investigating the behavior of human serum albumin following exposure to peroxynitrite. Peroxynitrite, at relative concentrations ranging from 0.2 to 50 with respect to protein… CONTINUE READING
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