Site-selective effect of bicarbonate on amantadine renal transport: quinine-sensitive in proximal vs quinidine-sensitive sites in distal tubules.

@article{Escobar1995SiteselectiveEO,
  title={Site-selective effect of bicarbonate on amantadine renal transport: quinine-sensitive in proximal vs quinidine-sensitive sites in distal tubules.},
  author={Miguel R Escobar and Daniel S. Sitar},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 1},
  pages={72-9}
}
The mechanism for bicarbonate enhancement of amantadine (A+) uptake was studied further. A selective modulatory effect of bicarbonate on the stereoselectivity of inhibition of A+ uptake by the stereoisomers, quinine (Q) and quinidine (QD), as reflected by the reversal of potency (Q > QD in KHS vs. QD > Q in phosphate), is reported. Studies were performed in bicarbonate (KHS) and phosphate buffers using purified cortical proximal (PT) and distal tubules (DT) from rat kidneys. Variations of… CONTINUE READING