Site-selective bromination of sp3 C–H bonds† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04611a

A method for converting sp3 C-H to C-Br bonds using an N-methyl sulfamate directing group is described. The reaction employs Rh2(oct)4 and a mixture of NaBr and NaOCl and is performed in aqueous solution open to air. For all sulfamates examined, oxidation occurs with high selectivity at the γ-carbon, affording a uniquely predictable method for C-H bond… CONTINUE READING