Site-selective binding of nanoparticles to double-stranded DNA via peptide nucleic acid "invasion".

Abstract

We demonstrate a novel method for by-design placement of nano-objects along double-stranded (ds) DNA. A molecular intercalator, designed as a peptide nucleic acid (PNA)-DNA chimera, is able to invade dsDNA at the PNA-side due to the hybridization specificity between PNA and one of the duplex strands. At the same time, the single-stranded (ss) DNA tail of… (More)
DOI: 10.1021/nn101355n

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