Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes

  title={Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes},
  author={Stipan Jonji{\'c} and Wolfgang Mutter and Frank Weiland and Matthias J. Reddehase and Ulrich H. Koszinowski},
  journal={The Journal of Experimental Medicine},
  pages={1199 - 1212}
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense… 

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