Site of blood vessel damage and relevance of CD18 in a murine model of immune complex-mediated vasculitis.

@article{Sindrilaru2007SiteOB,
  title={Site of blood vessel damage and relevance of CD18 in a murine model of immune complex-mediated vasculitis.},
  author={Anca Sindrilaru and Stephan Seeliger and Jan Mauno Ehrchen and Thorsten Peters and Johannes Roth and Karin Scharffetter-Kochanek and Cord H Sunderk{\"o}tter},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 2},
  pages={447-54}
}
How neutrophils (polymorphonuclear neutrophils, PMNs) damage vessels in leukocytoclastic vasculitis (LcV) mediated by immune complexes (ICs) is unclear. If degradative enzymes and oxygen radicals are released from PMNs while adhering to the inner side of the vessel wall, they could be washed away by the blood stream or neutralized by serum protease inhibitors. We investigated if in LcV PMNs could damage vessels from the tissue side after transmigration. We used CD18-deficient (CD18-/-) mice… CONTINUE READING