Site of action of grayanotoxins in mad honey in rats

  title={Site of action of grayanotoxins in mad honey in rats},
  author={Filiz Onat and Berrak Ç. Yeğen and Roger Lawrence and Ahmet Afşin Oktay and Şule Oktay},
  journal={Journal of Applied Toxicology},
Grayanotoxins are known to occur in honey produced from the nectar of Rhododendrons of the family Ericaceae. Grayanotoxins extracted from honey sample obtained from a patient who experienced severe bradycardia and hypotension after ingesting two tablespoonfuls corresponded to Rhododendron ponticum tetrades. Anaesthetized albino rats were injected with honey extract intracerebroventricularly or intraperitoneally. The intracerebroventricular dose was equivalent to 50 mg honey and i.p. doses were… Expand
Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats.
It has been observed that both Grayanotoxin and high dose Rhododendron honey treatments showed oxidant effect on blood plasma and organ tissues investigated. Expand
The dose-dependent cardiovascular effects of intravenous grayanotoxin-III in rats
It was found that the lethal dose of grayanotoxin-III for rats is 50 μg/kg, and in addition the death was developed due to cardiac arrest, in case of the lower level of 5 μg/ kggrayanot toxin-III, any toxic effect was not seen. Expand
Clinical review of grayanotoxin/mad honey poisoning past and present
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Investigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivo.
Rhododendron honey (RH) is obtained from the rhododendron plants are grown in many regions around the world, causes poisoning in humans due to the grayanotoxin (GTX) compound in its structure. It isExpand
Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond
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Electroencephalographic and behavioral effects of intracerebroventricular or intraperitoneal injections of toxic honey extract in adult Wistar rats and GAERS
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Grayanotoxin Poisoning: 'Mad Honey Disease' and Beyond Suze A. JansenIris Kleerekooper • Zonne L. M. HofmanIsabelle F. P. M. Kappen • Anna Stary-WeinzingerMarcel A. G. van der Heyden
Consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, hypotension and atrial-ventricular block. Expand
Pseudocholinesterase levels are not decreased in grayanotoxin (mad honey) poisoning in most patients.
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Poisoning by mad honey: a brief review.
  • I. Koca, A. Koca
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
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Investigation of the Toxic Effects of Rhododendron Honey on Mouse Cardiac Muscle Tissue Lipids at Molecular Level
The purpose of this study is to investigate the effects of different concentrations of Rhododendron honey (RH) on mouse cardiac muscle lipids by Attenuated Total Reflection Fourier Transform InfraredExpand


Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice.
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Rhododendrons, mountain laurel, and mad honey.
One of the earliest reports of poisoning was the mass intoxication that resulted from the ingestion of honey produced from the nectar of Rhododendron ponticum , which was described by Xenophon in theExpand
Is the site of action of grayanotoxin the sodium channel gating of squid axon?
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The pharmacological properties of toxic nectars obtained from several Rhododendron sp. Expand
Tobacco and cancer of the tongue in young adults.
A review of the patient registry of The University of Texas M. D. Anderson Hospital and Tumor Institute between 1944 and 1984 has revealed a significant increase in squamous cell carcinoma of the tongue among young adults (younger than age 40 years) (Table). Expand
Mechanism of nerve membrane depolarization caused by grayanotoxin I
1. The mechanism of depolarization of squid axon membranes caused by grayanotoxin I has been studied by means of internal perfusion and voltage clamp techniques.
Modulation of sodium channels of squid nerve membranes by grayanotoxin I.