Site of action of grayanotoxins in mad honey in rats

@article{Onat1991SiteOA,
  title={Site of action of grayanotoxins in mad honey in rats},
  author={Filiz Onat and Berrak Ç. Yeğen and Roger Lawrence and Ahmet Afşin Oktay and Şule Oktay},
  journal={Journal of Applied Toxicology},
  year={1991},
  volume={11}
}
Grayanotoxins are known to occur in honey produced from the nectar of Rhododendrons of the family Ericaceae. Grayanotoxins extracted from honey sample obtained from a patient who experienced severe bradycardia and hypotension after ingesting two tablespoonfuls corresponded to Rhododendron ponticum tetrades. Anaesthetized albino rats were injected with honey extract intracerebroventricularly or intraperitoneally. The intracerebroventricular dose was equivalent to 50 mg honey and i.p. doses were… Expand
Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats.
TLDR
It has been observed that both Grayanotoxin and high dose Rhododendron honey treatments showed oxidant effect on blood plasma and organ tissues investigated. Expand
The dose-dependent cardiovascular effects of intravenous grayanotoxin-III in rats
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It was found that the lethal dose of grayanotoxin-III for rats is 50 μg/kg, and in addition the death was developed due to cardiac arrest, in case of the lower level of 5 μg/ kggrayanot toxin-III, any toxic effect was not seen. Expand
Clinical review of grayanotoxin/mad honey poisoning past and present
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A pooled analysis of the dysrhythmias occurring in 69 patients from 11 different studies and reports is presented and the pathophysiology, signs, symptoms, clinical course, and treatment of grayanotoxin/mad honey poisoning are discussed. Expand
Investigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivo.
Rhododendron honey (RH) is obtained from the rhododendron plants are grown in many regions around the world, causes poisoning in humans due to the grayanotoxin (GTX) compound in its structure. It isExpand
Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond
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Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins, which have the potential to be harmful to humans and animals. Expand
Electroencephalographic and behavioral effects of intracerebroventricular or intraperitoneal injections of toxic honey extract in adult Wistar rats and GAERS
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The results suggest that the icv administration of toxic honey extract can be used as a seizure model in Wistar rats or in genetic absence epilepsy rats from Strasbourg. Expand
Grayanotoxin Poisoning: 'Mad Honey Disease' and Beyond Suze A. JansenIris Kleerekooper • Zonne L. M. HofmanIsabelle F. P. M. Kappen • Anna Stary-WeinzingerMarcel A. G. van der Heyden
TLDR
Consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, hypotension and atrial-ventricular block. Expand
Pseudocholinesterase levels are not decreased in grayanotoxin (mad honey) poisoning in most patients.
BACKGROUND The symptoms of mad honey poisoning resemble those of cholinergic toxidromes; however, it is not clear whether they share a common biochemical basis. OBJECTIVES The aim of this study wasExpand
Poisoning by mad honey: a brief review.
  • I. Koca, A. Koca
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
TLDR
The eating of 'mad honey (deli bal in Turkish)' contaminated by Rhododendron nectar grayanotoxins is a common food intoxications encountered for humans and livestock in Turkey. Expand
Investigation of the Toxic Effects of Rhododendron Honey on Mouse Cardiac Muscle Tissue Lipids at Molecular Level
The purpose of this study is to investigate the effects of different concentrations of Rhododendron honey (RH) on mouse cardiac muscle lipids by Attenuated Total Reflection Fourier Transform InfraredExpand
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References

SHOWING 1-10 OF 10 REFERENCES
Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice.
Abstract A toxic honey sample from Grouse Mountain, British Columbia, was shown to contain grayanotoxin II and grayanotoxin III, compounds closely related to grayanotoxin I (andromedotoxin), togetherExpand
Rhododendrons, mountain laurel, and mad honey.
One of the earliest reports of poisoning was the mass intoxication that resulted from the ingestion of honey produced from the nectar of Rhododendron ponticum , which was described by Xenophon in theExpand
Is the site of action of grayanotoxin the sodium channel gating of squid axon?
TLDR
This finding strongly suggests that the site of action of grayanotoxin (GTX) is not confined to the channel gating but is present in a part of the Na channel having both voltage sensor and ion filter functions. Expand
PHARMACOLOGICAL AND CHEMICAL OBSERVATIONS ON SOME TOXIC NECTARS
TLDR
The pharmacological properties of toxic nectars obtained from several Rhododendron sp. Expand
Tobacco and cancer of the tongue in young adults.
TLDR
A review of the patient registry of The University of Texas M. D. Anderson Hospital and Tumor Institute between 1944 and 1984 has revealed a significant increase in squamous cell carcinoma of the tongue among young adults (younger than age 40 years) (Table). Expand
Mechanism of nerve membrane depolarization caused by grayanotoxin I
1. The mechanism of depolarization of squid axon membranes caused by grayanotoxin I has been studied by means of internal perfusion and voltage clamp techniques.
Modulation of sodium channels of squid nerve membranes by grayanotoxin I.