Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.

@article{Gao2000SitedirectedMS,
  title={Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.},
  author={Zhi Gao and Qiying Jiang and Kenneth A. Jacobson and Adriaan P. IJzerman},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 5},
  pages={661-8}
}
To provide insights into interactions between ligands and A(2A) adenosine receptors, site-directed mutagenesis was used to test the roles of a glutamic acid residue in the first transmembrane domain (Glu13) and a histidine residue in the seventh transmembrane domain (His278). The two residues, which have been suggested to be closely linked in molecular… CONTINUE READING