Site-directed and natural mutations in studying functional domains in guanylyl cyclase activating proteins (GCAPs).

Abstract

Guanylyl cyclase activating proteins (GCAPs) are Ca2+-binding proteins of the EF-hand superfamily, through which the intracellular calcium regulates cGMP synthesis in vertebrate photoreceptors. GCAPs play an essential role in the calcium feedback mechanism that controls recovery and light adaptation of rods and cones. Moreover, mutations in at least one of… (More)

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Cite this paper

@article{Dizhoor2002SitedirectedAN, title={Site-directed and natural mutations in studying functional domains in guanylyl cyclase activating proteins (GCAPs).}, author={Alexander M. Dizhoor}, journal={Advances in experimental medicine and biology}, year={2002}, volume={514}, pages={291-301} }