Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors

@article{Haller2007SitedependentDK,
  title={Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors},
  author={Florian Haller and Nicole Happel and Hans-Juergen Schulten and Anja von Heydebreck and Stefanie Schwager and Thomas Armbrust and Claus Langer and Bastian Gunawan and Detlef Doenecke and L{\'a}szl{\'o} F{\"u}zesi},
  journal={Modern Pathology},
  year={2007},
  volume={20},
  pages={1103-1111}
}
In gastrointestinal stromal tumors (GISTs), mutually exclusive gain-of-function mutations of KIT and PDGFRA are associated with different mutation-dependent clinical behavior. Taking into account the well-known different clinical behavior of GISTs from the stomach or the intestine, the aim of the current study is to evaluate the mutation- and site-dependent effects on mRNA and protein expression of KIT and PDGFRA in a large series of primary GISTs. Fresh-frozen tissue of 53 primary GISTs from… CONTINUE READING

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Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors

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