Site-dependent central effects of aldosterone in rats.

  title={Site-dependent central effects of aldosterone in rats.},
  author={R L Dundore and J. N. D. Wurpel and Carey D. Balaban and Thomas Stephen Harrison and Lanny C. Keil and Jennifer Seaton and Walter B. Severs},
  journal={Brain research},
  volume={401 1},
A relationship between the subcommissural organ (SCO) and the adrenal glands has long been suspected. This report provides further information about the effects of a continuous D-aldosterone infusion into the SCO area of conscious, adult male Sprague-Dawley rats. A 6-day aldosterone infusion (5 ng/h) increased urinary sodium excretion, decreased adrenal medullary cross-sectional area, elevated adrenal corticosterone content and terminal plasma epinephrine concentration. Mineralocorticoid… CONTINUE READING
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