Site- and cell-type- specific induction of intestinal inducible nitric oxide synthase in a rat model of endotoxemia.

@article{Takahashi2005SiteAC,
  title={Site- and cell-type- specific induction of intestinal inducible nitric oxide synthase in a rat model of endotoxemia.},
  author={Toru Takahashi and Hajime Fujii and Hiroko Shimizu and Emiko Omori and Kenji Uehara and Masaharu Takeuchi and Masaki Matsumi and Masataka Yokoyama and Reiko Akagi and Kiyoshi Morita},
  journal={Medicinal chemistry (Shariqah (United Arab Emirates))},
  year={2005},
  volume={1 6},
  pages={643-7}
}
The intestine is one of the major organs that are involved in sepsis. The inducible isoform of nitric oxide synthase (iNOS) is known to play a critical role in the pathogenesis of septic tissue injury by generating excess amount of nitric oxide (NO) in response to cytokines and endotoxin. In this study, we examined changes in gene expression of iNOS in various regions of the intestine as well as the distribution of iNOS protein in the intestinal cells in a rat model of endotoxemia produced by… CONTINUE READING

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