Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs

@article{KissLszl1996SiteSpecificRM,
  title={Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs},
  author={Z. Kiss-L{\'a}szl{\'o} and Y. Henry and Jean-Pierre Bachellerie and M. Caizergues-Ferrer and T. Kiss},
  journal={Cell},
  year={1996},
  volume={85},
  pages={1077-1088}
}
Eukaryotic cells contain many fibrillarin-associated small nucleolar RNAs (snoRNAs) that possess long complementarities to mature rRNAs. Characterization of 21 novel antisense snoRNAs from human cells followed by genetic depletion and reconstitution studies on yeast U24 snoRNA provides evidence that this class of snoRNAs is required for site-specific 2'-O-methylation of preribosomal RNA (pre-rRNA). Antisense sno-RNAs function through direct base-pairing interactions with pre-rRNA. The antisense… Expand
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