Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.

Abstract

Site-specific conjugation technologies enable the production of homogeneous antibody-drug conjugates (ADCs) with improved therapeutic indices compared to conventional ADCs. However, current site-specific conjugation methods can only attach one type of drug to a single antibody. Given the emergence of acquired resistance to current ADCs, arming single… (More)
DOI: 10.1021/acs.bioconjchem.5b00244

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