Site-Specific Cation Release Drives Actin Filament Severing by Vertebrate Cofilin

@inproceedings{Kang2015SiteSpecificCR,
  title={Site-Specific Cation Release Drives Actin Filament Severing by Vertebrate Cofilin},
  author={Hyeran Kang and Michael J. Bradley and Wu-Chun Cao and Kaifeng Zhou and Elena E. Grintsevich and Alph{\'e}e Michelot and Emil Reisler and Charles Vaughn Sindelar and Mark Hochstrasser and Enrique Medina de la Cruz},
  year={2015}
}
Actin polymerization powers the directed motility of eukaryotic cells. Sustained motility requires rapid filament turnover and subunit recycling. The essential regulatory protein cofilin severs actin filaments, which accelerates network remodeling by increasing the concentration of filament ends available for elongation and subunit exchange. Although cofilin effects on actin filament assembly dynamics have been extensively studied, the molecular mechanism of cofilin-induced filament severing is… CONTINUE READING

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Actin Mechanics and Fragmentation.

  • The Journal of biological chemistry
  • 2015
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