Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

@article{Greiner2015SiteSelectiveMO,
  title={Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.},
  author={Vanille J Greiner and Lesia Kovalenko and Nicolas Humbert and Ludovic Richert and Catherine Birck and Marc Ruff and Olga A Zaporozhets and Sirano dhe-Paganon and Christian Bronner and Yves M{\'e}ly},
  journal={Biochemistry},
  year={2015},
  volume={54 39},
  pages={6012-20}
}
UHRF1 plays a central role in the maintenance and transmission of epigenetic modifications by recruiting DNMT1 to hemimethylated CpG sites via its SET and RING-associated (SRA) domain, ensuring error-free duplication of methylation profiles. To characterize SRA-induced changes in the conformation and dynamics of a target 12 bp DNA duplex as a function of… CONTINUE READING