Site-Selective Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II as a Synaptic Encoding Mechanism

@article{Coomber1998SiteSelectiveAO,
  title={Site-Selective Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II as a Synaptic Encoding Mechanism},
  author={Christopher J. Coomber},
  journal={Neural Computation},
  year={1998},
  volume={10},
  pages={1653-1678}
}
A detailed kinetic model of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is presented in which subunits undergo autophosphorylation at several sites in a manner that depends on the frequency and duration of Ca2+ spikes. It is shown that high-frequency stimulation causes autophosphorylation of the autonomy site (Thr286), and promotes persistent catalytic activity. On the other hand, low-frequency stimulation is shown to cause autophosphorylation of an inhibitory site (Thr306), which… CONTINUE READING
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The influence of prior synaptic activity on the induction of long-term potentiation

  • Huang, Y-Y, A. Colino, D. K. Selig, R. C. Malenka
  • Science
  • 1992
Highly Influential
2 Excerpts

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