Site-1 protease is essential for endochondral bone formation in mice

Abstract

Site-1 protease (S1P) has an essential function in the conversion of latent, membrane-bound transcription factors to their free, active form. In mammals, abundant expression of S1P in chondrocytes suggests an involvement in chondrocyte function. To determine the requirement of S1P in cartilage and bone development, we have created cartilage-specific S1P… (More)

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Cite this paper

@article{Patra2007Site1PI, title={Site-1 protease is essential for endochondral bone formation in mice}, author={Debabrata Patra and Xiaoyun Xing and Sherri R Davies and Jenny Bryan and Carl Franz and Ernst Bruno Hunziker and Linda J. Sandell}, journal={The Journal of Cell Biology}, year={2007}, volume={179}, pages={687 - 700} }