Sitagliptin in the treatment of type 2 diabetes: a meta‐analysis

@article{Zhan2012SitagliptinIT,
  title={Sitagliptin in the treatment of type 2 diabetes: a meta‐analysis},
  author={Mei Zhan and Ting Xu and Fengbo Wu and Yao Tang},
  journal={Journal of Evidence‐Based Medicine},
  year={2012},
  volume={5}
}
  • M. Zhan, T. Xu, +1 author Yao Tang
  • Published 1 August 2012
  • Medicine
  • Journal of Evidence‐Based Medicine
Objective: To evaluate the benefits and harms of sitagliptin in people with type 2 diabetes mellitus. 
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The overall HbA1c-lowering effect and incidence of AE were similar for sitagli leptin, vildagliptin and saxaglipt in Chinese adults with newly diagnosed diabetes. Expand
Efficacy of mitiglinide and sitagliptin, alone or in combination, on postprandial excursion and glycemic variability assessed by continuous glucose monitoring: a post hoc analysis with single-day treatment
TLDR
Mitiglinide or combination treatment resulted in lower glycemic variability and postprandial glucose excursion than sitagliptin alone; however, the results of this single-day pharmacodynamics study cannot be generalized to a clinical setting. Expand
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References

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Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes
Aim: To compare the efficacy and safety of monotherapy with sitagliptin and metformin in treatment‐naïve patients with type 2 diabetes.
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
Objective: To evaluate the efficacy and tolerability of sitagliptin when added to insulin therapy alone or in combination with metformin in patients with type 2 diabetes.
Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes *
TLDR
The addition of sitagliptin to ongoing metformin therapy in patients with type 2 diabetes who were inadequately controlled on met formin monotherapy is assessed. Expand
Efficacy and safety of the dipeptidyl peptidase‐4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double‐blind, non‐inferiority trial
TLDR
The primary aim is to compare the efficacy and safety of sitagliptin vs. glipizide in patients with type 2 diabetes and inadequate glycaemic control on metformin monotherapy. Expand
Efficacy and safety of the dipeptidyl peptidase‐4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
TLDR
To assess the efficacy and safety of a 24‐week treatment with sitagliptin, a highly selective once‐daily oral dipeptidyl peptidase‐4 (DPP‐4) inhibitor, in patients with type 2 diabetes who had inadequate glycaemic control while on glimepiride alone or in combination with metformin. Expand
Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients.
TLDR
The addition of both sitagliptin or metformin to pioglitazone gave an improvement of HbA(1c), FPG, and PPG; but met formin led also to a decrease of body weight and to a faster and better improvement of insulin resistance and inflammatory state parameters, even if sitaglisptin produced a better protection of beta-cell function. Expand
Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea.
TLDR
In this study, sitagliptin monotherapy for 18 weeks significantly improved glycemic control and was well-tolerated in patients with type 2 diabetes from China, India, and Korea. Expand
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
TLDR
Sitagliptin significantly improved glycaemia control and was well tolerated in patients with type 2 diabetes mellitus who had inadequate glycaemic control on exercise and diet. Expand
Treatment options for type 2 diabetes: introducing the incretin-based therapies
diabetes mellitus (T2DM), glycaemic control is often difficult to maintain and current treatments can produce adverse effects. The incretin-based therapies - dipeptidyl peptidase-4 inhibitors andExpand
Sitagliptin: A Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
TLDR
Review of the literature to date implies sitagliptin may be effective as monotherapy in type 2 diabetes, and existing evidence supports the use of sitgliptin as adjunct therapy to sulfonylureas and metformin. Expand
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