Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes.

@article{Scalzo2019SitagliptinID,
  title={Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes.},
  author={R. Scalzo and D. Rafferty and I. Schauer and A. Huebschmann and M. Cree-Green and J. Reusch and J. Regensteiner},
  journal={Journal of diabetes and its complications},
  year={2019}
}
BACKGROUND People with type 2 diabetes mellitus (T2D) have preclinical cardiac and vascular dysfunction associated with low cardiorespiratory fitness (CRF). This is especially concerning because CRF is a powerful predictor of cardiovascular mortality, a primary issue in T2D management. Glucagon-like pepetide-1 (GLP-1) augments cardiovascular function and our previous data in rodents demonstrate that potentiating the GLP-1 signal with a dipeptidyl peptidase-4 (DPP4) inhibitor augments CRF… Expand

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