Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis

@inproceedings{Engel2010SitagliptinRO,
  title={Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis},
  author={Samuel S Engel and DEBORA E. WILLIAMS-HERMAN and Gregory T. Golm and Ron Clay and Samuel V. Machotka and Keith D. Kaufman and Barry J. Goldstein},
  booktitle={International journal of clinical practice},
  year={2010}
}
Recent case reports of acute pancreatitis in patients with type 2 diabetes (T2DM) treated with incretin-based therapies have triggered interest regarding the possibility of a mechanism-based association between pancreatitis and glucagon-like peptide-1 mimetics or dipeptidyl peptidase-4 (DPP-4) inhibitors. The objective of this review was to describe the controlled preclinical and clinical trial data regarding the incidence of pancreatitis with sitagliptin, the first DPP-4 inhibitor approved for… CONTINUE READING

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