Sister-chromatid exchanges induced by trihalomethanes in rat erythroblastic cells and their suppression by crude catechin extracted from green tea.


An in vitro sister-chromatid exchange (SCE) assay using rat erythroblastic leukemia cells was conducted with four major trihalomethanes (THMs): chloroform, CHCl3; dichlorobromomethane, CHCl2Br, dibromochloromethane, CHClBr2; bromoform, CHBr3. In the absence of S9 mix, CHBr3, CHClBr2 and CHCl2Br significantly induced SCEs in a clear dose-dependent manner… (More)


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