Sister-chromatid exchanges in human lymphocytes exposed to 1-p-(3-methyltriazeno)benzoic acid potassium salt.

@article{Vernole1988SisterchromatidEI,
  title={Sister-chromatid exchanges in human lymphocytes exposed to 1-p-(3-methyltriazeno)benzoic acid potassium salt.},
  author={Patrizia Vernole and Daniela Caporossi and Bruna Tedeschi and Gerry Melino and Berardino Porfirio and Enzo Bonmassar and B. Nicoletti},
  journal={Mutation research},
  year={1988},
  volume={208 3-4},
  pages={233-6}
}
The 1-p-(3-methyltriazeno) benzoic acid potassium salt (MTBA) is a triazeno analogue of dacarbazine, an antineoplastic agent capable of mediating the appearance of new antigenic specificities on cancer cells in mice, a phenomenon described as 'chemical xenogenization' (CX). Recently we reported the clastogenic potential of MTBA on human lymphocytes. Since sister-chromatid exchange (SCE) assay is more sensitive than clastogenic tests, at least at low drug concentrations, we assessed SCE… CONTINUE READING