Sister-chromatid exchange induction by sodium selenite: plasma protein-bound selenium is not the active SCE-inducing metabolite of Na2SeO3.

@article{Ray1982SisterchromatidEI,
  title={Sister-chromatid exchange induction by sodium selenite: plasma protein-bound selenium is not the active SCE-inducing metabolite of Na2SeO3.},
  author={James H. Ray and Lewis C. Altenburg},
  journal={Mutation research},
  year={1982},
  volume={102 3},
  pages={285-96}
}
Sodium selenite (Na2SeO3) is an anticarcinogenic/antimutagenic/anticlastogenic agent that under certain incubation conditions induces sister-chromatid exchanges (SCEs), unscheduled DNA synthesis, and chromosome aberrations. Previous work has shown that SCE induction by Na2SeO3 depends on the presence of red blood cells (RBCs). Therefore, Na2SeO3 uptake and release by RBCs was studied in the present report as was the effect of plasma protein-bound selenium, the end product of Na2SeO3 metabolism… CONTINUE READING