Sister chromatid exchange in human chromosomes from normal individuals and epileptic patients on combinations of anticonvulsants.

Abstract

Sister chromatid exchange (SCE) frequency, a sensitive indicator in mutagenicity testing, and mitotic index (MI) have been studied to observe genotoxic effects in epileptic patients on routine combinations of anticonvulsant therapy. All patients, both male and female and from various age groups, revealed an increased frequency of SCE per metaphase and a low… (More)

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@article{Goyle1989SisterCE, title={Sister chromatid exchange in human chromosomes from normal individuals and epileptic patients on combinations of anticonvulsants.}, author={Sandeep Goyle and Anand Kumar Maurya and Umesh Kumar Rout and S. Kailash and Manish Maheshwari}, journal={Teratogenesis, carcinogenesis, and mutagenesis}, year={1989}, volume={9 1}, pages={7-14} }