Sister chromatid exchange assay as a predictor of tumor chemoresponse.

@article{Mourelatos2016SisterCE,
  title={Sister chromatid exchange assay as a predictor of tumor chemoresponse.},
  author={D. Mourelatos},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2016},
  volume={803-804},
  pages={
          1-12
        }
}
  • D. Mourelatos
  • Published 2016
  • Medicine
  • Mutation research. Genetic toxicology and environmental mutagenesis
Sister Chromatid Exchanges (SCEs) are known to enhance as a consequence of exposure to various mutagenic agents and appear to indicate DNA damaging effects and/or subsequent repair by homologous recombination (HR). DNA damage plays an interesting role in the majority of mechanisms underlying the effects of antitumor drugs, since the genetic activity of the plethora of these agents is due to their ability to damage the DNA. The DNA-effects of antitumor agents towards normal cells (genotoxicity… Expand
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