Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide.

@article{Sharief1986SisterCE,
  title={Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide.},
  author={Yousuf Sharief and A. V. Brown and Lorraine C. Backer and John A. Campbell and Barbara Westbrook-Collins and Andrew G. Stead and James W Allen},
  journal={Environmental mutagenesis},
  year={1986},
  volume={8 3},
  pages={439-48}
}
The use of polymers in plastic and rubber products has generated concern that monomers potentially active in biological systems may be eluted from these substances. We have evaluated two such monomers, acrylonitrile and styrene, for the induction of chromosome damage in mice. Butadiene monoxide, a presumed metabolite of a third important monomer, 1,3-butadiene, was also tested. These chemicals were administered as a single intraperitoneal injection; sister chromatid exchanges and chromosome… CONTINUE READING

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