Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination

@article{Kim2010SisterCA,
  title={Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination},
  author={Keun Pil Kim and Beth M. Weiner and Liangran Zhang and Amy Y Jordan and Job Dekker and Nancy Kleckner},
  journal={Cell},
  year={2010},
  volume={143},
  pages={924-937}
}
Meiotic double-strand break (DSB)-initiated recombination must occur between homologous maternal and paternal chromosomes ("homolog bias"), even though sister chromatids are present. Through physical recombination analyses, we show that sister cohesion, normally mediated by meiotic cohesin Rec8, promotes "sister bias"; that meiosis-specific axis components Red1/Mek1kinase counteract this effect, thereby satisfying an essential precondition for homolog bias; and that other components, probably… CONTINUE READING
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Meiotic Recombination

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