Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.

  title={Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.},
  author={William C. Hallows and Susan Lee and John M Denu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 27},
Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD(+)-dependent deacetylases that modulate gene silencing, aging and energy metabolism. Previous work has implicated several transcription factors as sirtuin targets. Here, we investigated whether mammalian sirtuins could directly control the activity of metabolic enzymes. We demonstrate that mammalian Acetyl-CoA synthetases (AceCSs) are regulated by reversible acetylation and that sirtuins activate AceCSs by deacetylation. Site… CONTINUE READING
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