Sirtuins as emerging anti-parasitic targets.

  • Weiping Zheng
  • Published 2013 in European journal of medicinal chemistry


Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of NAD(+)-dependent protein N(ε)-acetyl-lysine (AcK) deacetylases. Sirtuins are also evolutionarily conserved proteins that are present in all kingdoms of life ranging from bacteria to humans. Interestingly, it was recently found that the sirtuins found in various human parasites… (More)
DOI: 10.1016/j.ejmech.2012.11.014


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