Sirtuins and Disease: The Road Ahead

@inproceedings{Carafa2012SirtuinsAD,
  title={Sirtuins and Disease: The Road Ahead},
  author={Vincenzo Carafa and Angela Nebbioso and Lucia Altucci},
  booktitle={Front. Pharmacol.},
  year={2012}
}
Sirtuins represent a promising new class of conserved histone deacetylases, originally identified in yeast. The activity of the sirtuin (SirT) family - made up of seven members (SirT1-7) - is NAD(+) dependent. Sirtuins target a wide range of cellular proteins in nucleus, cytoplasm, and mitochondria for post-translational modification by acetylation (SirT1, 2, 3, and 5) or ADP-ribosylation (SirT4 and 6). Sirtuins regulate responses to stress and ensure that damaged DNA is not propagated, thus… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Sirtuins and disease

  • L Altucci
  • 2012

malian Sirt 1 : insight on its biological functions

  • A. Schuetz, J. Min, +8 authors A. N. Plotnikov
  • Cell Commun . Signal
  • 2011

Similar Papers

Loading similar papers…