Sirtuins and Disease: The Road Ahead

  title={Sirtuins and Disease: The Road Ahead},
  author={Vincenzo Carafa and Angela Nebbioso and Lucia Altucci},
  booktitle={Front. Pharmacol.},
Sirtuins represent a promising new class of conserved histone deacetylases, originally identified in yeast. The activity of the sirtuin (SirT) family - made up of seven members (SirT1-7) - is NAD(+) dependent. Sirtuins target a wide range of cellular proteins in nucleus, cytoplasm, and mitochondria for post-translational modification by acetylation (SirT1, 2, 3, and 5) or ADP-ribosylation (SirT4 and 6). Sirtuins regulate responses to stress and ensure that damaged DNA is not propagated, thus… CONTINUE READING


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