Sirtuins — novel therapeutic targets to treat age-associated diseases

  title={Sirtuins — novel therapeutic targets to treat age-associated diseases},
  author={Siva Lavu and Olivier Boss and Peter J. Elliott and Philip D. Lambert},
  journal={Nature Reviews Drug Discovery},
Sirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation–deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of metabolic, neurodegenerative and inflammatory diseases, and so hold promise for drug discovery efforts in multiple therapeutic areas. Here, we discuss current knowledge and data that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 177 extracted citations


Publications referenced by this paper.
Showing 1-10 of 176 references

Anti-inflammatory effect of resveratrol on TNF-a-induced MCP-1 expression in adipocytes

  • J Zhu
  • Biochem. Biophys. Res. Commun. 369,
  • 2008

Inhibition of NF-kB signaling by longevity factors FoxOs and SIRT1

  • Salminen, A. et al. Interaction of aging-associated signaling cascades
  • Cell. Mol. Life Sci. 65, 1049–1058
  • 2008

Similar Papers

Loading similar papers…