Sirtuins: the 'magnificent seven', function, metabolism and longevity.

  title={Sirtuins: the 'magnificent seven', function, metabolism and longevity.},
  author={N Dali-youcef and Marie Lagouge and Sebastien C Froelich and Christian Koehl and Kristina Schoonjans and Johan Auwerx},
  journal={Annals of medicine},
  volume={39 5},
The sirtuin family of histone deacetylases (HDACs) was named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has been shown to mediate the effects of calorie restriction on the extension of life span and high levels of Sir2 activity promote longevity. Like their yeast homologs, the mammalian sirtuins (SIRT1-7) are class III HDACs and require NAD(+) as a cofactor to deacetylate substrates ranging from histones to transcriptional… CONTINUE READING
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