Sirtuins: common targets in aging and in neurodegeneration.

  title={Sirtuins: common targets in aging and in neurodegeneration.},
  author={Rita Machado de Oliveira and Teresa Faria Pais and Tiago F Outeiro},
  journal={Current drug targets},
  volume={11 10},
Aging has been a subject of interest since primordial times. More recently, it became clear that aging is the major known risk factor for several neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. A major focus in the field of aging is to examine whether the genetic regulators of lifespan also regulate the trigger and/or progression of age-related disorders. Sirtuins, which belong to the Sir2 family of NAD(+)-dependent deacetylases, are known… CONTINUE READING

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